Synthesis and characterization of expanded radialenes, bisradialenes, and radiaannulenes

Article abstract of DOI:10.1002/anie.200703978

(Figure Presented) Room for expansion: A versatile protocol for the synthesis of a new generation of strained cross-conjugated macrocycles (expanded radialenes) has been achieved. This method uses the Sonogashira cross-coupling reaction to prepare expanded radialenes, bisradialenes, and radiaannulenes. Preliminary electronic, redox, and structural characterization of the macrocycles are presented.

Full text of DOI:10.1002/anie.200703978

Angewandte
Chemie
DOI: 10.1002/anie.200703978
Cross-Coupling Reactions
Synthesis and Characterization of Expanded Radialenes, Bisradialenes,
and Radiaannulenes**
Mojtaba Gholami, Frederic Melin, Robert McDonald, Michael J. Ferguson, Luis Echegoyen, and
Rik R. Tykwinski*
Shape-persistent, conjugated macrocycles have been designed
to exhibit a broad spectrum of interesting attributes and
topologies.[1] Over the past two decades amazing progress has
been made towards the synthesis of these macrocycles, which
have remarkable electronic, optical, nonlinear optical, and
supramolecular properties.[2–4] A subset of this general class of
molecules are the radialenes (1) and expanded radialenes (2
and 3; see Scheme 1), which arise from the formal insertion of
acetylene units into the framework of a radialene molecule.[5]
A related class of macrocycles, radiaannulenes (4, Scheme 1),
contain both endo- and exocyclic vinyl segments within the
conjugated core.[6] Both the expanded radialenes and the
radiaannulenes are cross-conjugated macrocycles,[3,4] and
their rigid two-dimensional structure provides a useful frame-
work for the development of fundamentally interesting p-rich
molecules. The study of expanded radialenes was initiated by
Diederich and co-workers,[7] who explored the rich chemistry
of butadiynyl-based radialenes 3 and radiaannulenes 4. These
studies, and others, used a combination of functional group
variation and extensive analysis of their physical properties,
and have suggested that molecules such as 3 and 4 can be
Scheme 1. Structures of radialenes, expanded radialenes, and radiaan-
nulenes.
generated with intriguing optical and electronic properties.[3,4]
Radialenes 2 would be expected to share many of the
attractive electronic characteristics of their larger cousins 3.
Furthermore, a recent computational study has suggested that
upon a single-electron reduction, a trimeric derivative of 2
[*] M. Gholami, Prof. Dr. R. R. Tykwinski
(n = 0) should become antiaromatic.[8] To date, however, the
Department of Chemistry
University of Alberta
Edmonton, AB, T6G 2G2 (Canada)
synthesis of radialenes 2 has proved challenging, and only a
single example has been reported (2, n = 3, R = alkyl).[9]
Fax: (+1)780-492-8231
E-mail: rik.tykwinski@ualberta.ca
Herein, we report a general protocol for the synthesis of
expanded radialenes 5–8 from acyclic oligomers 9–12 and
vinyl bromide 13 (Scheme 2). Also described are our initial
efforts to extend this method through coupling with tetra-
bromoethane (14) to generate the first examples of enyne
bisradialenes, namely 15 and 18, and radiaannulenes, namely
16 and 17. Finally, the structural (X-ray crystallography),
electronic (cyclic voltammetry), and optical (absorbance and
emission) properties of the isolated macrocycles 5–7, 15/16,
and 17 are described.
Dr. F. Melin, Prof. Dr. L. Echegoyen
Department of Chemistry
Clemson University
Clemson, South Carolina, 29634 (USA)
E-mail: luis@clemson.edu
Dr. R. McDonald, Dr. M. J. Ferguson
X-ray Crystallography Laboratory
Department of Chemistry
University of Alberta
Edmonton, Alberta, T6G 2G2 (Canada)
The new expanded radialenes were synthesized from
enyne oligomers 9–12,[10] which were desilylated and then
reacted with 13 under Pd-catalyzed Sonogashira conditions
(Scheme 2).[11] For example, dimer 9 was desilylated with
tetra-n-butylammonium fluoride (TBAF) in wet THF to give
the terminal diyne. Following workup, the diyne was then
reacted with 13 in the presence of [Pd(PPh3)4], CuI, and
iPr2NH in THF at reflux to give the highly strained expanded
[3]radialene 5 in a reasonable yield of 32%. The successful
ring closure to give 5 provides a noteworthy achievement of
[**] The financial support provided by the University of Alberta, the
Natural Sciences and Engineering Research Council of Canada
(NSERC), and the National Science Foundation (grant number
CHE-0509989) is greatly appreciated. This material is based on work
supported by the National Science Foundation while L.E. was
working here. All opinions, findings, conclusions, and recommen-
dations expressed herein are those of the authors and do not
necessarily reflect the views of the National Science Foundation.
Supporting information for this article is available on the WWW
under http://www.angewandte.org or from the author.
Angew. Chem. Int. Ed. 2007, 46, 9081 –9085
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Scheme 2. Synthesis of expanded radialenes 5–8 (the linearly conju-
gated ene-yne-ene segment is highlighted in bold). R=SiMe2tBu.
the Sonogashira reaction to effect bond formation in an
incredibly strained cyclic system.[12]
Based on the same strategy, trimer 10 and tetramer 11
were used in a similar manner to synthesize [4]- and
[5]radialenes 6 and 7 in yields of 75 and 45%, respectively.
Attempts to form the analogous [6]radialene 8, however,
resulted in only very poor yields, with the macrocycle derived
from the intramolecular oxidative acetylenic homocoupling[13]
of desilylated 12 being isolated as the major product
(64%).[14] The difficulty in forming 8 most likely arises from
the significant steric crowding originating from the 12
pendent phenyl rings, which reduces the ability of this
macrocycle to approach the approximately planar conforma-
tion that would favor ring closure.
Scheme 3. Synthesis of expanded bisradialene 15 and radiaannulene
16.
Spectroscopically, all three radialenes 5–7 share the
common feature of only seven unique resonances in their
13C NMR spectra as a result of their symmetry. Of note is the
consistent shift of particular resonances as a result of the
increased ring strain, as has been noted for other acetylenic
macrocycles.[15] For example, the resonance of the exocyclic
vinylidene carbon atom is the most diagnostic, and this signal
shifts upfield from d = 155 ppm for [5]radialene 7 to d =
146 ppm for the most strained [3]radialene 5.
Carbon-rich, highly conjugated bisexpanded radialene
and radiaannulene compounds were then prepared through a
single-step reaction of the corresponding enyne precursor
with tetrabromoethene (14, Scheme 3). Thus, trimeric 10 was
desilylated and treated with 14 for 18 h under conditions
analogous to those for the synthesis of radialenes 5–7.
Separation of the major reaction product by chromatography
gave an orange solid that MALDI-TOF mass spectrometric
(MS) analysis showed was consistent with the expected
product(s) 15 and/or 16. 13C NMR spectroscopic analysis of
this material showed that more than one product was present,
but gave little indication of which compound had formed
preferentially. Unfortunately, all subsequent attempts to
separate the isomers were unsuccessful, although HPLC
analysis showed an approximate 2:1 ratio of products.[14] X-
ray crystallography ultimately confirmed bisradialene 15 was
likely to be the predominant product (see below).
Scheme 4. Synthesis of expanded radiaannulene 17 and bisradialene
18.
product in 18% yield. 13C NMR spectroscopic analysis of this
product identified 13 resonances (out of the 14 expected),
which were consistent with the structure of either 17 or 18.
The constitution of the product was ultimately confirmed to
be 17 by X-ray crystallography (see below). A trace amount
of a second product was tentatively identified as 18 on the
basis of MALDI-TOF MS analysis.
The absorption spectra of the expanded radialenes 5–7
were measured in THFat room temperature.[16] The spectra of
6 and 7 show a single strong absorption at lmax = 377 nm (e =
99300 LmolÀ1 cmÀ1)
and
lmax = 374 nm
(e =
Desilylation of dimeric 9, followed by treatment with 14
gave a dark red-purple solid (Scheme 4), which MALDI-TOF
MS data indicated was consistent with the formation of
product(s) 17 and/or 18. Although this solid was only poorly
soluble in common organic solvents, thus making purification
a challenge, separation by preparative TLC did provide a pure
51300 LmolÀ1 cmÀ1), respectively, with
a
much weaker
shoulder absorption for 6 at approximately 420 nm. The
major difference between radialenes 6 and 7 is the lower
molar absorptivity of 7, which may arise from its more flexible
and nonplanar structure. Conversely, [3]radialene 5 shows
two major maxima at lmax = 364 nm (e = 105300 LmolÀ1 cmÀ1)
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Angewandte
Chemie
and 415 nm (e = 107500 LmolÀ1 cmÀ1). At present, the origin
of the more significant lower energy absorption for 5 is not yet
understood. It may be the result of an augmentation of the
shoulder signal observed for 6 as a result of the decreased
conformational flexibility in the more strained structure of 5.
Conversely, it may arise from an increase in macrocyclic
cross-conjugation, which has been invoked to account for the
red shift in the lmax values observed for trimeric derivatives of
the larger expanded radialenes 3.[4,17] The latter argument is
supported through a comparison of the lmax values for 5–7
The electrochemical properties of 5–7 and 17 were
measured in CH2Cl2 containing 0.1m nBu4PF6 and with a 3-
mm diameter glassy carbon disk as the working electrode
(Figure 1). Ferrocene was added at the end of the experiments
and used as an internal reference for measuring the potentials.
Despite the different size of their cross-conjugated macro-
with those of the acyclic precursors 9–11, which show lmax
=
374 nm when measured in THF.[10,18] Since the longest linearly
conjugated segment is identical in 5–7 and 9–11 (shown in
bold in Scheme 2), the low-energy absorption of 5 must arise
from other factors.[19]
The high-energy region of the absorption spectrum of
radiaannulene 17 shows an absorption similar to that of
radialenes 5–7 (at lmax = 381 nm, e = 63000 LmolÀ1 cmÀ1).[16]
The low-energy region is, however, quite dissimilar from
those of 5–7 and shows two additional maxima at lmax
534 nm and 572 nm (e =
=
(e = 19500 LmolÀ1 cmÀ1)
31700 LmolÀ1 cmÀ1), which signify a substantial lowering of
the gap between the highest occupied molecular orbital and
lowest unoccupied molecular orbital (HOMO–LUMO). It is
unlikely that this lowering of the HOMO–LUMO gap derives
simply from an extension of the linearly conjugated segment
of 17, since the oligodiacetylene 19, synthesized by Giesa and
Figure 1. Cyclic voltammagrams of radialenes 5–7 and radiaannulene
17 measured in CH2Cl2 + 0.1m nBu4PF6 (scan rate 100 mVsÀ1). Fc+/
Fc =ferrocenium/ferrocene couple.
cyclic framework, expanded radialenes 5–7 showed compa-
rable redox behavior. For these three compounds two
reduction steps were observed, the first reversible at À2.0 V
versus Fc+/Fc and the second was less well defined at À2.2 V
versus Fc+/Fc. A single, one-electron, reversible oxidation
step at 0.8 V was also observed (Table 1). Therefore, no
significant lowering of the electrochemical HOMO–LUMO
gap was observed for compound 5, despite its lower energy
absorption in the UV/Vis region. The same trend was found
for the larger expanded radialenes 3, as described by Die-
derich and co-workers, where similar redox potentials were
observed irrespective of the size of the macrocycle (n = 1–
3).[21] The smaller radialenes 5–7 are considerably more
difficult to reduce than any of the reported radialenes 3.[17,21]
The difficult reduction of compound 5 may substantiate the
prediction of Chauvin and co-workers[8] that a one-electron
reduction of a [3]radialene analogue to 5 (i.e., 2 n = 0, R = H)
should lead to an antiaromatic molecule, although this
premise inspires the analysis of additional substitution
patterns (which is currently under investigation). In contrast
to 5–7, radiannulene 17 was both easier to reduce and oxidize,
Schulz, shows lmax = 418 nm; which is over 100 nm higher in
energy than that of radiaannulene 17 despite its longer linear
conjugated segment.[20] Thus, it seems clear that the con-
strained, cross-conjugated framework of 17 plays a major role
in the electronic makeup of this compound.
While isomers 15 and 16 could not be separated to allow
for UV/Vis analysis of each isomer individually, an empirical
comparison to 17 is nonetheless interesting. The mixture of 15
and 16 shows the same high-energy absorption maximum at
387 nm as found for 17, as well as a single broadened low-
energy absorption maximum at 509 nm, albeit blue shifted
versus that of 17. Thus, the mixture of 15 and 16 also seems to
exhibit unique electronic characteristics resulting from their
macrocyclic structure.
The fluorescence spectra of compounds 5–7 (lexc
=
380 nm, THF, room temperature) show a single broad
emission peak (lem) with similar relative intensities. The
observed Stokes shift increases as a function of the size of the
macrocycle (lem: 5: 498 nm, 6: 525 nm, 7: 544 nm), and can be
attributed to increased molecular flexibility in the larger
Table 1: Peak and half-wave potentials of the first reduction and
oxidation steps of expanded radialenes 5–7 and radiaannulene 17.
Cmpd Epc red.1 Epa red.1 E1/2 red.1 Epa ox.1 Epc ox.1 E1/2 ox.1
5
6
7
17
À1.99
À1.98
À1.98
À1.40
À1.92
À1.91
À1.91
À1.33
À1.96
À1.94
À1.94
À1.36
0.82
0.81
0.83
0.71
0.75
0.75
0.76
0.64
0.79
0.78
0.80
0.68
cycles. Compound 17 shows an intense emission at lem
=
594 nm, and the emission wavelength does not vary as a
function of the excitation wavelength (lexc = 380, 533, or
571 nm).
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Communications
which is consistent with the UV/Vis absorption data that
showed a smaller HOMO–LUMO gap for 17. Compound 17
presented two reversible one-electron reductions at À1.36 V
and À1.71 V versus Fc+/Fc and a reversible one-electron
oxidation at 0.68 V versus Fc+/Fc.
Single crystal X-ray analysis of 6 (Figure 2) shows a planar
cyclic core, with the pendent phenyl groups twisted from this
plane in a manner that facilitates p–p stacking interactions. In
contrast, the structure of 7 is not planar,[14] and its cyclic core
resembles an envelope conformation, which likely arises from
increased steric interactions between the pendent phenyl
rings.
Figure 3. ORTEP drawing of radiaannulene 17. Thermal ellipsoids are
drawn at the 20% probability level. Selected bond angles [8]: C1’-C1-
C11’ 119.7(4), C2-C1-C11’ 122.3(3), C1’-C1-C2 118.0(4), C1-C2-C3
171.0(4), C2-C3-C4 164.2(4), C3-C4-C6 106.9(3), C4-C6-C7 158.1(3),
C6-C7-C8 159.6(3), C7-C8-C10 105.7(3), C8-C10-C11 161.1(4), C1’-C11-
C10 173.6(4).
Figure 2. ORTEP drawing of radialene 6. Thermal ellipsoids are drawn
at the 20% probability level. Selected bond angles [8]: C2-C1-C7’
168.23(14), C1-C2-C3 166.65(14), C2-C3-C5 110.40(12), C3-C5-C6
172.20(15), C5-C6-C7 171.30(15), C1’-C7-C6 110.40(11).
A comparison of structures 6 and 7 confirms the increased
strain found in the former. While bond lengths for both fall
within similar ranges, the bond angles within the macrocyclic
ꢀ À
cores differ quite dramatically. The C C C bond angles for 6
Figure 4. ORTEP drawing illustrating both the structure and disorder
of the cocrystallite formed from bisradialene 15 and radiaannulene 16.
Thermal ellipsoids are drawn at the 20% probability level. Selected
bond angles [8]: C1A-C2A-C3 172.6(9), C2A-C3-C4 160.4(6), C1A-C12A-
C11 172.7(9), C1B-C2B-C3 174.6(19), C2B-C3-C4 175.2(10), C1B’-C12B-
C11 178.9(16), C10-C11-C12B 175.8(9), C3-C4-C5 109.8(3), C4-C5-C6
170.3(3), C5-C6-C7 167.1(3), C6-C7-C8 109.9(3), C7-C8-C9 165.4(3),
C8-C9-C10 171.3(3), C9-C10-C11 110.9(3), C10-C11-C12A 160.6(5).
range from 166.78 to 172.28 (average: 169.68), while those for
7 range from 171.08 to 177.48 (average: 173.78). The endocy-
clic alkylidene bond angles also show the effect of ring strain,
with both unique angles of 6 observed at 110.48, and those of 7
ranging from 111.78 to 113.58 (average: 112.68).
Crystals of radiaannulene 17 were grown from THF/
pentane at 4–58C and X-ray analysis shows that the cyclic
core of this molecule adopts a planar geometry (Figure 3).
À
À
The endocyclic alkylidene bond angles C7 C8 C10 at
ethenes core in the solid state, the spatial arrangement of the
remaining atoms of the structure is shared by both molecules.
Unlike 17, neither 15 nor 16 are planar: both have a
stretched chair conformation.[14] The structure of 15 shares
À
À
105.7(3)8 and C3 C4 C6 at 106.9(3)8 are significantly smaller
than those observed for either 6 or 7 and reflect the significant
ring strain in the framework. The alkyne bond angles of 17 are
also substantially reduced from optimal values, and range
from 158.1(3)8 to 173.6(4)8 (average: 164.68).
ꢀ À
many similarities to that of [4]radialene 6, including C C C
bond angles that average 167.68 (range: 160.48 to 172.78).
Radiaannulene 16 is the next higher analogue of 17, and
shows substantially less ring strain than 17 with an average
bond angle of 172.38 (range: 165.58 to 178.98) and also internal
alkylidene bond angles that are between 110 and 1118. A
comparison of the bond angles for structures 15 and 16 shows
that the bisradialene is clearly the more strained of the two.
Bisradialene 15 and radiaannulene 16 cocrystallize from
CHCl3 and with various ratios of the two molecules in the
crystalline state depending on the initial sample (in the
structure shown here, a 15:16 ratio of 2:1 is observed,
Figure 4). The two structures are remarkably similar, and
while they are disordered about the central tetraethynyl-
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Angewandte
Chemie
9.028(2) Š; V= 4885.5(19) Š3; Z = 4; 1calcd = 1.198 gcmÀ3
;
m =
In conclusion, the synthesis of a new class of stable
expanded radialenes and radiaannulenes has been demon-
strated. This study has shown that macrocycles with incredibly
strained conjugated enyne structures can be synthesized by
Sonogashira cross-coupling reactions. UV/Vis absorption
spectroscopy indicates that the electronic characteristics of
the expanded radialenes are related to their macrocyclic
cross-conjugated framework, and that the more strained the
structure, the more interesting the electronic properties. A
study of the fundamental structure–property relationships for
these and related compounds is currently underway.
0.068 mmÀ1
;
T= À808C; R1(F) = 0.0619 (2135 reflections F2o ꢁ
2s(F2o)) and wR2 = 0.1837 for all 4304 unique data. CCDC-652685
(6), 652686 (7), 652687 (15 and 16), and 652688 (17) contain the
supplementary crystallographic data for this paper. These data can be
obtained free of charge from The Cambridge Crystallographic Data
Centre via www.ccdc.cam.ac.uk/data_request/cif.
Received: August 29, 2007
Published online: October 26, 2007
Keywords: cross-conjugation · cross-coupling · macrocycles ·
.
radiaannulenes · radialenes
Experimental Section
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5: Yellow solid. M.p. 185–1868C; UV/Vis (THF): lmax (e LmolÀ1 cmÀ1
)
;
364 (105300), 415 nm (107500); IR (CH2Cl2, cast): n˜ = 3055 cmÀ1
1H NMR (400 MHz, CD2Cl2): d = 7.61–7.57 (m, 12H), 7.42–7.39 ppm
(m, 18H); 13C NMR (125 MHz, CD2Cl2): d = 146.2, 139.7, 130.7,
129.5, 128.3, 107.2, 92.5 ppm. EI HRMS calcd for C48H30 [M+]:
606.2347, found: 606.2354.
6: Yellow solid. M.p. 305–3068C (decomp); UV/Vis (THF): lmax
(e LmolÀ1 cmÀ1) 377 nm (99300); IR (CH2Cl2, cast): n˜ = 3050 cmÀ1
;
1H NMR (400 MHz, CDCl3): d = 7.26–7.16 (m, 24H), 7.08 ppm (t, J =
6.6 Hz, 16H); 13C NMR (125 MHz, CD2Cl2): d = 151.8, 140.1, 130.2,
129.1, 128.3, 102.6, 97.1 ppm; MALDI-TOF MS (trans-2-(3-(4-tert-
butylphenyl)-2-methyl-2-propenylidene)malononitrile, DCTB) calcd
for C64H40 [M+]: 808.3, found: 808.2 (100).
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Chem. Int. Ed. Engl. 1992, 31, 931 – 954.
[6] F. Mitzel, C. Boudon, J. P. Gisselbrecht, P. Seiler, M. Gross, F.
Diederich, Helv. Chim. Acta 2004, 87, 1130 – 1157.
[7] J. Anthony, A. M. Boldi, C. Boudon, J.-P. Gisselbrecht, M. Gross,
P. Seiler, C. B. Knobler, F. Diederich, Helv. Chim. Acta 1995, 78,
797 – 817.
[8] C. Lepetit, M. B. Nielsen, F. Diederich, R. Chauvin, Chem. Eur.
J. 2003, 9, 5056 – 5066.
[9] S. Eisler, R. R. Tykwinski, Angew. Chem. 1999, 111, 2138 – 2141;
Angew. Chem. Int. Ed. 1999, 38, 1940 – 1943.
7: Yellow solid. M.p. 300–3018C (decomp); UV/Vis (THF): lmax
(e LmolÀ1 cmÀ1) 374 nm (51300); IR (CH2Cl2, cast): n˜ = 3051 cmÀ1
;
1H NMR (300 MHz, CDCl3): d = 7.18–7.13 (m, 30H), 7.08 ppm (t, J =
7.2 Hz, 20H); 13C NMR (125 MHz, CD2Cl2): d = 155.2, 140.4, 130.6,
129.3, 128.1, 101.9, 90.7 ppm; MALDI-TOF MS (DCTB) calcd for
C80H50 [M+]: 1010.4, found: 1010.4 (100).
17: Red-purple solid. M.p. 250–2518C (decomp); UV/Vis (THF):
lmax (e LmolÀ1 cmÀ1
)
381 nm (63000), 534 nm (19500), 572 nm
(31700); IR (CH2Cl2, cast): n˜ = 3057, 2141 cmÀ1 1H NMR
;
(300 MHz, CDCl3): d = 7.54–7.30 ppm (m, 40H); 13C NMR
(125 MHz, CD2Cl2): d = 149.0, 139.7, 139.4, 130.8, 130.6, 129.8,
129.7, 128.4, 128.3, 104.4, 102.9, 101.5, 96.0 ppm (one resonance was
not observed). MALDI-TOF MS (DCTB) calcd C70H40for [M+]:
880.3, found: 880.2 (100).
[10] Y. Zhao, A. D. Slepkov, C. O. Akoto, R. McDonald, F. A.
Hegmann, R. R. Tykwinski, Chem. Eur. J. 2005, 11, 321 – 329.
[11] a) K. Sonogashira, Y. Tohda, N. Hagihara, Tetrahedron Lett.
1975, 16, 4467 – 4470; b) R. R. Tykwinski, Angew. Chem. 2003,
115, 1604 – 1606; Angew. Chem. Int. Ed. 2003, 42, 1566 – 1568.
ꢀ À
[12] The C C C bond angles for 5 are calculated to be 1588: AM1
15 and 16: Orange solid. M.p. 295–2968C (decomp); UV/Vis
(THF): lmax (e LmolÀ1 cmÀ1) 387 nm (139400), 509 nm (38900); IR
(CH2Cl2, cast): n˜ = 3052, 2153, 1442 cmÀ1. MALDI-TOF MS (DCTB)
calcd for C102H60 [M+]: 1285.5, found: 1285.5 (100).
geometry minimization, Spartanꢂ02 v1.0.6, Wavefunction, Inc.
[13] P. Siemsen, R. C. Livingston, F. Diederich, Angew. Chem. 2000,
112, 2740 – 2767; Angew. Chem. Int. Ed. 2000, 39, 2632 – 2657.
[14] See the Supporting Information for details.
Crystallographic data for 6: C64H40·2C4H8O, Mr = 953.17, triclinic,
¯
[15] S. Eisler, R. McDonald, G. R. Loppnow, R. R. Tykwinski, J. Am.
Chem. Soc. 2000, 122, 6917 – 6928.
[16] See the Supporting Information for spectra.
[17] M. B. Nielsen, M. Schreiber, Y. G. Baek, P. Seiler, S. Lecomte, C.
Boudon, R. R. Tykwinski, J.-P. Gisselbrecht, V. Gramlich, P. J.
Skinner, C. Bosshard, P. Gꢀnter, M. Gross, F. Diederich, Chem.
Eur. J. 2001, 7, 3263 – 3280.
[18] C. A. Lewis, R. R. Tykwinski, Chem. Commun. 2006, 3625 –
3627.
[19] It is possible that molecular symmetry and the associated
selection rules also contribute to the differences observed in the
electronic transitions of 5–7, as has recently been outlined for
cyclic oligothiophenes, see A. Bhaskar, G. Ramakrishna, K.
Hagedorn, O. Varnavski, E. Mena-Osteritz, P. Bꢃuerle, T.
Goodson III, J. Phys. Chem. B 2007, 111, 946 – 954.
[20] R. Giesa, R. C. Schulz, Polym. Int. 1994, 33, 43 – 60.
[21] J. P. Gisselbrecht, N. N. P. Moonen, C. Boudon, M. B. Nielsen, F.
Diederich, M. Gross, Eur. J. Org. Chem. 2004, 2959 – 2972.
space group P1 (no. 2); a = 7.1300(5), b = 10.7812(8), c =
17.0015(12) Š; a = 78.4123(14), b = 89.7067(15), g = 85.7118(14)8;
V= 12762.62 (16) Š3; Z = 1; 1calcd = 1.240 gcmÀ3; m = 0.073 mmÀ1
;
T= À808C; R1(F) = 0.0478 (3382 reflections F2o ꢁ 2s(Fo2)) and wR2 =
0.1267 for all 5189 unique data.
Crystallographic data for 7: C80H50, Mr = 1011.20, monoclinic,
space group P21/n (an alternate setting of P21/c (no. 14)); a =
16.5917(10), b = 16.7378(10), c = 20.4413(12) Š; b = 90.5758(12)8;
V= 5676.4(6) Š3; Z = 4; 1calcd = 1.183 gcmÀ3; m = 0.067 mmÀ1; T=
À808C; R1(F) = 0.0514 (6933 reflections F2o ꢁ 2s(Fo2)) and wR2 =
0.1381 for all 11629 unique data.
Crystallographic data for 15 and 16: C102H60·3CHCl3, Mr =
¯
1643.60, triclinic, space group P1 (no. 2); a = 9.1206(9), b =
13.8110(13), c = 17.4081(17) Š; a = 98.2298(16), b = 93.2189(16), g =
106.1213(16)8; V= 2074.2(3) Š3; Z = 1; 1calcd = 1.316 gcmÀ3
; m =
0.354 mmÀ1
;
T= À808C; R1(F) = 0.0835 (5020 reflections F2o ꢁ
2s(F2o)) and wR2 = 0.2758 for all 7288 unique data.
Crystallographic data for 17: C70H40, Mr = 881.02, orthorhombic,
space group Pbca (no. 61); a = 27.982(6), b = 19.339(4), c =
Angew. Chem. Int. Ed. 2007, 46, 9081 –9085
ꢀ 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
www.angewandte.org 9085
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