Tetrahedron Letters p. 2571 - 2574 (1985)
Update date:2022-09-26
Topics: Synthesis Phenols Heterocyclic Imidazo[1,2-a]pyridine
Rydzkowski, R.
Blondeau, D.
Sliwa, H.
Preparation of the unknown title compound has been achieved by condensation of 2-amino-3-hydroxy-pyridine with chloroacetaldehyde.Activation by the free phenolic hydroxyl allows preferential nitration of the pyridine ring, in marked contrast to the behavior of the related ethers which suffer electrophilic substitution on the imidazole moiety, as usual in the series.
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(1985)
