
Tetrahedron Letters p. 2873 - 2876 (1985)
Update date:2022-07-29
Topics:
Mead, Dennis
Loh, Rhonda
Asato, A. E.
Liu, R. S. H.
Piperidine-acetic acid catalyzed crossed aldol condensation of 1,1,1-trifluoroacetone with aryl or α,β-unsaturated aldehydes was found to be a useful method for the preparation of unsaturated trifluoromethyl ketones.Chain extension of these ketones led to several new fluorinated retinoids including the hitherto elusive all-trans isomers of 19,19,19- and 20,20,20-trifluororetinal.
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