Tetrahedron Letters p. 3345 - 3348 (1985)
Update date:2022-08-03
Topics:
Botta, Maurizio
Angelis, Francesco De
Finizia, Gabriella
Nicoletti, Rosario
Transformation of 6- and 5,6-dialkyl-2-methoxy-4(3H)-pyrimidinones (1a and 1b) into 1-N-acylated-pyrimidine derivatives 3(a-f) under Friedel-Craft like conditions is presented.In different acylation conditions 4-O-acylated-pyrimidines (5a and 5b) are also obtained.Compounds (3c) and (3f) can be direcly converted into 1-N-acyl-protected-isouridine analogues (8a and 8b).
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