TRIS(3,6-DIOXAHEPTYL)AMINE: A SUPERIOR COMPLEXING AGENT FOR DISSOLVING METAL REACTIONS

Article abstract of DOI:10.1016/S0040-4039(00)95452-2

Commercially available tris(3,6-dioxaheptyl)amine (TDA-1) is an effective phase transfer catalyst for reactions with sodium-potassium alloy in tetrahydrofuran.Deoxygenation of acetates, dehalogenation, and hydrolysis of tosylates and mesylates proceed in high yield.The use of a deuterated alcohol during deoxygenation reactions leads to site-specific deuteration.