Journal of Organic Chemistry p. 774 - 787 (2020)
Update date:2022-07-29
Topics:
Mao, Chun-Li
Zhao, Sheng
Zang, Zhong-Lin
Xiao, Lin
Zhou, Cheng-He
He, Yun
Cai, Gui-Xin
A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only E-selective highly substituted 1,3-diene derivatives with extra-ligand-free and good functional group tolerance including estrone and free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate directing group enables the formation of unique alkenyl palladacycle intermediates.
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Doi:10.1016/j.bmc.2012.02.004
(2012)Doi:10.14233/ajchem.2016.19676
(2016)Doi:10.1007/s00726-011-1117-6
(2012)Doi:10.1021/ja01373a037
(1930)Doi:10.1021/ja01490a054
(1960)Doi:10.1002/jhet.35
(2009)