Synthesis of 2'-Deoxy-5-monofluoromethyluridine (FTDR) and 2'-Deoxy-5-difluoromethyluridine (F2TDR)

DOI: 10.1039/c39850001535

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Journal of the Chemical Society. Chemical communications p. 1535 - 1536 (1985)

Update date:2022-08-04

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Authors:

Matulic-Adamic, Jasenka

Watanabe, Kyoichi A.

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Article abstract of DOI:10.1039/c39850001535

The synthesis of potential anticancer and antitumour nucleosides, 2'-deoxy-5-monofluoromethyluridine (FTDR) and 2'-deoxy-5-difluoromethyluridine (F2TDR) was achieved in four steps from thymidine including monosilylation with t-butyldiphenylsilyl chloride,

Full text of DOI:10.1039/c39850001535

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