Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]- 4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole

DOI: 10.1016/j.bmcl.2007.12.036

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 963 - 968 (2008)

Update date:2022-07-30

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Authors:

Srivastava, Brijesh Kumar

Soni, Rina

Joharapurkar, Amit

Sairam, Kalapatapu V.V.M.

Patel, Jayendra Z.

Goswami, Amitgiri

Shedage, Sandeep A.

Kar, Sidhartha S.

Salunke, Rahul P.

Gugale, Shivaji B.

Dhawas, Amol

Kadam, Pravin

Mishra, Bhupendra

Sadhwani, Nisha

Unadkat, Vishal B.

Mitra, Prasenjit

Jain, Mukul R.

Patel, Pankaj R.

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Article abstract of DOI:10.1016/j.bmcl.2007.12.036

Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]- 4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) 2 is reported. Computer assisted conf

Full text of DOI:10.1016/j.bmcl.2007.12.036

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