Syntheses and Antifolate Activity of 5-Methyl-5-deaza Analogues of Aminopterin, Methotrexate, Folic Acid, and N10-Methylfolic Acid

DOI: 10.1021/jm00156a029

Source and publish data:

Journal of Medicinal Chemistry p. 1080 - 1087 (1986)

Update date:2022-07-31

Topics:

Authors:

Piper, J. R.

McCaleb, G. S.

Montgomery, J. A.

Kisliuk, R. L.

Gaumont, Y.

Sirotnak, F. M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00156a029

Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaz

Full text of DOI:10.1021/jm00156a029

Products guided by the article

Product name:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

Cas No:101810-78-0

R&D Labs maybe for 101810-78-0

Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Xi'an Costrong Pharmaceutical Co., Ltd.

Contact:029- 68576496

Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
QINGDAO HONG JIN CHEMICAL CO.,LTD.

website:http://www.hongjinchem.com

Contact:+86-532-83657313

Address:2ND Building, 8 Shangqing Road, Qingdao, Shandong Province, China.
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
NEM CHEMICAL CO.，LTD

website:http://www.NEM.COM.CN

Contact:+86-393-4411771

Address:The west section of shengli Road,Puyang,Henan Province,China

Relevant to this article

Stereochemistry of cycloaddition of (S)-N-(1-phenylethyl)-C-diethoxyphosphorylated nitrone with vinyl acetate. Studies on mutarotation of 3-(O,O-diethylphosphoryl)-5-hydroxyisoxazolidines

Doi:10.1016/j.tetasy.2008.01.009
(2008)
Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids

Doi:10.1016/j.bmc.2007.11.050
(2008)
Highly active and green aminopropyl-immobilized phosphotungstic acid on mesocellular silica foam for the O-heterocyclization of cycloocta-1,5-diene with aqueous H₂O₂

Doi:10.1039/c0gc00691b
(2011)
O-SILYLATED ENOLATE PHENYLTHIOALKYLATION: A NEW SYNTHESIS OF UNSATURATED 1,5-DICARBONYL COMPOUNDS.

Doi:10.1016/S0040-4039(00)87352-9
(1982)
Metal chelates of benzeneazo-N-tosyl-2-naphthylamine

Doi:10.1134/S1070328408120063
(2008)
Synthesis of N-(L-glutam-5-oyl)-alpha-D-glucopyranosylamine and O-alpha-D-glucopyranosyl-(1 to 6)-O-beta-D-glucopyranosyl-(1 to 6)-N-(L-glutam-5-oyl)-alpha-D-glucopyranosylamine.

Doi:10.1016/S0008-6215(00)84977-0
(1982)

Article Doi