Journal of Medicinal Chemistry p. 1080 - 1087 (1986)
Update date:2022-07-31
Topics:
Piper, J. R.
McCaleb, G. S.
Montgomery, J. A.
Kisliuk, R. L.
Gaumont, Y.
Sirotnak, F. M.
Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaz
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