Syntheses and Antifolate Activity of 5-Methyl-5-deaza Analogues of Aminopterin, Methotrexate, Folic Acid, and N10-Methylfolic Acid

DOI: 10.1021/jm00156a029

Source and publish data:

Journal of Medicinal Chemistry p. 1080 - 1087 (1986)

Update date:2022-07-31

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Authors:

Piper, J. R.

McCaleb, G. S.

Montgomery, J. A.

Kisliuk, R. L.

Gaumont, Y.

Sirotnak, F. M.

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Article abstract of DOI:10.1021/jm00156a029

Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaz

Full text of DOI:10.1021/jm00156a029

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