Antagonists of substance P. Further modifications of substance P antagonists obtained by replacing either positions 7, 9 or 7, 8 and 11 of SP with D-amino acid residues.

DOI: 10.1021/jm00157a009

Source and publish data:

Journal of medicinal chemistry p. 1171 - 1178 (1986)

Update date:2022-09-26

Topics:

Authors:

Dutta Dutta

Gormley Gormley

Graham Graham

Briggs Briggs

Growcott

Jamieson

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Article abstract of DOI:10.1021/jm00157a009

Antagonists of SP and the C-terminal (6-11)-hexapeptide have been obtained by multiple D-amino acid substitutions in various positions of SP and by protecting the N alpha-Arg1 and N epsilon Lys3 amino groups with benzyloxycarbonyl groups. On the guinea pi

Full text of DOI:10.1021/jm00157a009

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