A FACILE CLEAVAGE OF OXIRANE WITH HYDRAZOIC ACID IN DMF A NEW ROUTE TO CHIRAL β-HYDROXY-α-AMINO ACIDS

Article abstract of DOI:10.1016/S0040-4039(00)95024-X

Chiral β-hydroxy-α-amino acids such as erythro-β-hydroxy-L-aspartic acid and erythro-β-hydroxymethyl-L-serine derivatives have been synthesized in optically pure form from L- and D-tartaric acids through a novel oxirane ring-opening reaction and a selecti