Bioorganic and Medicinal Chemistry (2020)
Update date:2022-07-29
Topics: Synthesis Data Analysis Biological Assays Clinical Trials Literature Review Structure-Activity Relationship (SAR) Study Lead Optimization Toxicity and ADME Studies Market Launch Preclinical Testing Scale-Up Synthesis Project Goals and Compound Design Synthesis Planning Regulatory and Intellectual Property Considerations Data Submission and Review
Chen, Wenteng
Liu, Shuangrong
Liu, Xingyu
Pan, Youlu
Shao, Jiaan
The covalent binding nature of irreversible kinase inhibitors potentially increases the severity of “off-target” toxicity. Based on our continual strategy of chemically tuning the Michael addition acceptors, herein, we further explore the relationship amo
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