1-Oxo-3-substitute-isothiochroman-4-carboxylic acid compounds: Synthesis and biological activities of FAS inhibition

DOI: 10.1016/j.bmcl.2008.12.010

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 770 - 772 (2009)

Update date:2022-08-04

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Authors:

Wang, Xiaokui

Zhao, Guoming

Chen, Yao

Xu, Xiaowei

Zhong, Wu

Wang, Lili

Li, Song

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Article abstract of DOI:10.1016/j.bmcl.2008.12.010

A new series 1-oxo-3-substitute-isothiochroman-4-carboxylic acid compounds have been designed and synthesized. Screening of these molecules for FAS inhibition in vitro has indicated that compounds 2c and 2d showed more effective FAS inhibition activities

Full text of DOI:10.1016/j.bmcl.2008.12.010

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