Direct asymmetric aldol reaction catalyzed by simple prolinamide phenols

DOI: 10.1016/j.tetasy.2006.12.008

Source and publish data:

Tetrahedron Asymmetry p. 3351 - 3357 (2006)

Update date:2022-07-31

Topics: Column chromatography Yield NMR spectroscopy Enantiomeric excess (ee) Asymmetric catalysis TLC (thin-layer chromatography) HPLC (high-performance liquid chromatography) Organocatalysis Stereoselectivity Catalyst Loading Aldol Reaction Reaction Optimization Prolinamide Solvent screening β-hydroxy carbonyl compound

Authors:

Fu, Yu-Qin

Li, Zai-Chun

Ding, Li-Na

Tao, Jing-Chao

Zhang, Sheng-Hong

Tang, Ming-Sheng

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Article abstract of DOI:10.1016/j.tetasy.2006.12.008

Simple prolinamides 1a-f were synthesized, and their catalytic effects on the direct asymmetric aldol reactions in organic solvents and in water were evaluated. Prolinamide phenols 1a-d were found to be effective catalysts for the reaction of aromatic ald

Full text of DOI:10.1016/j.tetasy.2006.12.008

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