Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents

DOI: 10.1248/cpb.40.2720

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2720 - 2727 (1992)

Update date:2022-08-03

Topics:

Authors:

Terada Terada

Fujimoto

Nomura Nomura

Yamashita

Kobunai Kobunai

Takeda Takeda

Wierzba Wierzba

Yamada Yamada

Yamaguchi

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Article abstract of DOI:10.1248/cpb.40.2720

Various podophyllotoxin derivatives from desoxypodophyllotoxin (DPT) were synthesized to examine the structural relationships between the biological significance (cytotoxic effect, effects on DNA topoisomerase II and tubulin polymerization) in vitro and a

Full text of DOI:10.1248/cpb.40.2720

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