Synthesis of Short Oligoribonucleotides Bearing a 3'- or 5'-Terminal Phosphate by use of 4,4',4''-tris(4,5-dichlorophthalimido)trityl as a New 5'-Hydroxyl Protecting Group

Article abstract of DOI:10.1021/ja00275a052

Oligoribonucleotide synthesis by use of 4,4',4''-tris(4,5-dichlorophtalimido)trityl (CPTr) as a new 5'-hydroxyl protecting group is described.The reaction of N-protected 2'-O-(tetrahydropyran-2-yl) ribonucleosides with tris(4,5-dichlorophthalimido)trityl