A total synthesis of arenastatin A, an extremely potent cytotoxic depsipeptide, from the Okinawan marine sponge dysidea arenaria

DOI: 10.1248/cpb.42.2394

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2394 - 2396 (1994)

Update date:2022-07-31

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Authors:

Kobayashi

Kurosu Kurosu

Wang Wang

Kitagawa

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Article abstract of DOI:10.1248/cpb.42.2394

An asymmetric synthesis of a cyclic depsipeptide arenastatin A (1), which was isolated from the marine sponge Dysidea arenaria and exhibited extremely potent cytotoxicity with IC₅₀ 5 pg/ml for KB cells, has been accomplished.

Full text of DOI:10.1248/cpb.42.2394

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