Synthesis and anti-inflammatory activity of rac-2-(2,3-dihydro-1,4-benzodioxin)propionic acid and its R and S enantiomers

DOI: 10.1016/S0223-5234(97)84016-0

Source and publish data:

European Journal of Medicinal Chemistry p. 529 - 534 (1997)

Update date:2022-08-04

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Authors:

Vazquez Vazquez

Rosell Rosell

Pujol Pujol

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Article abstract of DOI:10.1016/S0223-5234(97)84016-0

Racemic (R,S)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)propionic acid (3) has been prepared from 2,3-dihydro-1,4-benzodioxin. R-(-)-Pantolactone has been used as auxiliary for the synthesis of R-3 and S-3. The anti-inflammatory properties of the new carboxylic acids are described and compared with other anti-inflammatory agents. The highest activity is exhibited by compound S-3.

Full text of DOI:10.1016/S0223-5234(97)84016-0

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