Chemical and Pharmaceutical Bulletin p. 529 - 538 (1993)
Update date:2022-08-04
Topics:
Ishihara
Miyamoto
Nakayama
Goto
Inhibitors of acetylcholinesterase (AChE) bave been designed based on a working hypothesis of the enzyme's active site. These compounds were tested for their inhibitory activities on AChE and ω-[N-ethyl-N-(phenylmethyl)amino]-1-phenyl-1-alkanones (3) were found to be potent inhibitors. Various analogues of 3 were prepared to study the effect on AChE inhibition of partial restriction of conformation. Compounds with potent AChE inhibition were further evaluated in terms of central selectivity: the ratio of central action (ameliorating effect on scopolamine-induced memory impairment using a T-maze alternation task) to peripheral action.
View MoreKaymossy BioChem Tech Co., Ltd
website:http://www.kaimosi.com
Contact:0571-87191913/0571-87199097
Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Contact:86-21 60347964
Address:No.1304, West Meilong Road, Minhang District, Shanghai, China
Shanghai Haoyuan Chemexpress Co., Ltd.
website:https://www.chemexpress.com/
Contact:86-21-58950125
Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Zhejiang Sucon Silicone Co.,Ltd
Contact:+86-575-88046692
Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Doi:10.1021/jo00335a002
(1981)Doi:10.1016/j.bmc.2008.01.047
(2008)Doi:10.1021/ja00127a038
(1995)Doi:10.1016/S0008-6215(00)80408-5
(1981)Doi:10.1039/c7nj04534d
(2018)Doi:10.1039/d0cc00959h
(2020)
