Isoquinoline formation via iminium ions cyclization: A direct approach to c-2′ functionalized 3-aryltetrahydroisoquinolines

DOI: 10.1016/0040-4020(95)00770-9

Source and publish data:

Tetrahedron p. 12159 - 12168 (1995)

Update date:2022-08-04

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Authors:

Sotomayor, Nuria

Dominguez, Esther

Lete, Esther

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Article abstract of DOI:10.1016/0040-4020(95)00770-9

3-Aryltetrahydroisoquinoline derivatives can be efficiently prepared by titanium tetrachloride promoted cyclization of N-methoxymethyl-N-1,2-diarylethylamines via iminium ions. In the case of primary amines, the 1-aryl group prevents the alkylation of a s

Full text of DOI:10.1016/0040-4020(95)00770-9

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