Isoquinoline formation via iminium ions cyclization: A direct approach to c-2′ functionalized 3-aryltetrahydroisoquinolines

Article abstract of DOI:10.1016/0040-4020(95)00770-9

3-Aryltetrahydroisoquinoline derivatives can be efficiently prepared by titanium tetrachloride promoted cyclization of N-methoxymethyl-N-1,2-diarylethylamines via iminium ions. In the case of primary amines, the 1-aryl group prevents the alkylation of a s