Synthetic Communications p. 2743 - 2749 (2004)
Update date:2022-07-30
Topics:
Robinson, Dale E.
Seth, Punit P.
Jefferson, Elizabeth A.
A new method for the solid-phase synthesis of N-aryl-N′-carboalkoxy guanidines is described. Aromatic amines were reacted with Fmoc-isothiocyanate to provide Fmoc-thioureas, which were coupled with Rink amide resin to provide the corresponding resin-bound Fmoc-guanidines. Subsequent Mitsunobu alkylation with a variety of alcohols delivered N-aryl-N′ carboalkoxy guanidines in good to high purity after resin cleavage.
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