Synthetic Communications p. 2743 - 2749 (2004)
Update date:2022-07-30
Topics:
Robinson, Dale E.
Seth, Punit P.
Jefferson, Elizabeth A.
A new method for the solid-phase synthesis of N-aryl-N′-carboalkoxy guanidines is described. Aromatic amines were reacted with Fmoc-isothiocyanate to provide Fmoc-thioureas, which were coupled with Rink amide resin to provide the corresponding resin-bound Fmoc-guanidines. Subsequent Mitsunobu alkylation with a variety of alcohols delivered N-aryl-N′ carboalkoxy guanidines in good to high purity after resin cleavage.
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Doi:10.1002/jhet.5570380122
(2001)Doi:10.1016/S0040-4020(01)85561-7
(1994)Doi:10.1021/jo000614m
(2000)Doi:10.1021/ja01127a009
(1952)Doi:10.1016/S0223-5234(97)89849-2
(1996)Doi:10.1021/ja910588w
(2010)