Peptidyl α-Ketoheterocyclic Inhibitors of Human Neutrophil Elastase. 2. Effect of Varying the Heterocyclic Ring on in Vitro Potency

DOI: 10.1021/jm00001a013

Source and publish data:

Journal of Medicinal Chemistry p. 76 - 85 (1995)

Update date:2022-08-05

Topics:

Authors:

Edwards, Philip D.

Wolanin, Donald J.

Andisik, Donald W.

Davis, Watthew W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00001a013

A series of peptidyl α-ketoheterocycles were synthesized and evaluated for their in vitro inhibition of human neutrophil elastase (HNE).Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r) with nano

Full text of DOI:10.1021/jm00001a013

Products guided by the article

Product name:[(S)-2-Methyl-1-(1-methyl-1H-imidazole-2-carbonyl)-propyl]-carbamic acid benzyl ester

Cas No:1027295-37-9

R&D Labs maybe for 1027295-37-9

Guangxi Bonger Pharmaceutical Co., Ltd

website:http://napo.lookchem.com/

Contact:+86-18817331185

Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
Hangzhou Showland Technology Co., Ltd.

Contact:86-571-88920516

Address:ROOM2118,NO.553,WENSAN ROAD,HANGZHOU,CHINA
Shanghai Forever Biotech Co., Ltd.

Contact:+86-21-69734790

Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing
jiangsu haian chemical co.,ltd.

Contact:86-513-15851283853

Address:No.99,Changjiang West Road,Haian County,Jiangsu Province,China

Relevant to this article

The total synthesis of bistratamides F-I

Doi:10.1016/j.tet.2004.10.024
(2005)
Orthocyclophanes. 4. Functionalization of <1_n>Ortocyclophanes on the Aromatic Rings

Doi:10.1021/jo00095a026
(1994)
A NEW SYNTHESIS OF IMIDOYL IODIDES VIA BECKMANN REARRANGEMENT OF OXIME SULFONATES

Doi:10.1016/S0040-4039(00)88149-6
(1983)
Synthesis of aryl-substituted 1,3-butadiones

Doi:10.1081/SCC-120016361
(2003)
Synthesis of 6-substituted 9-benzyl-8-hydroxypurines with potential interferon-inducing activity

Doi:10.1248/cpb.51.608
(2003)
The role of steric and electronic interactions in the stereocontrol of the asymmetric 1,3-dipolar reactions of 5-ethoxy-3-p-(S)-tolylsulfinylfuran-2(5H)-ones with diazoalkanes: Theoretical calculations and experimental evidences

Doi:10.1021/jo0345603
(2003)

Article Doi