Peptidyl α-Ketoheterocyclic Inhibitors of Human Neutrophil Elastase. 2. Effect of Varying the Heterocyclic Ring on in Vitro Potency

DOI: 10.1021/jm00001a013

Source and publish data:

Journal of Medicinal Chemistry p. 76 - 85 (1995)

Update date:2022-08-05

Topics:

Authors:

Edwards, Philip D.

Wolanin, Donald J.

Andisik, Donald W.

Davis, Watthew W.

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Article abstract of DOI:10.1021/jm00001a013

A series of peptidyl α-ketoheterocycles were synthesized and evaluated for their in vitro inhibition of human neutrophil elastase (HNE).Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r) with nano

Full text of DOI:10.1021/jm00001a013

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