Journal of Medicinal Chemistry p. 76 - 85 (1995)
Update date:2022-08-05
Topics:
Edwards, Philip D.
Wolanin, Donald J.
Andisik, Donald W.
Davis, Watthew W.
A series of peptidyl α-ketoheterocycles were synthesized and evaluated for their in vitro inhibition of human neutrophil elastase (HNE).Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r) with nano
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