Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: Synthesis and biological activities

DOI: 10.1021/jm00018a027

Source and publish data:

Journal of Medicinal Chemistry p. 3660 - 3668 (1995)

Update date:2022-08-02

Topics:

Authors:

Gangjee Gangjee

Zaveri Zaveri

Kothare Kothare

Queener Queener

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a027

Twenty 6-substituted 2,4-diaminotetrahydroquinazolines were designed, synthesized, and biologically evaluated as novel nonclassical inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. The 6

Full text of DOI:10.1021/jm00018a027

Products guided by the article

Product name:N-(2-Acetylamino-6-{[methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-5,6,7,8-tetrahydro-quinazolin-4-yl)-acetamide

Cas No:1027576-33-5

R&D Labs maybe for 1027576-33-5

Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Shochem(Shanghai) Co., Ltd

website:http://www.shochem.com

Contact:021-50800795

Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD

Contact:+86-531-55696072

Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Mashilabs(shanghai)Co.,ltd

Contact:+86-21-54391580

Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.

Relevant to this article

First asymmetric total syntheses of cernuane-type Lycopodium alkaloids cernuine, and cermizine D

Doi:10.1021/ol800574v
(2008)
A PALLADIUM MEDIATED REDUCTIVE CYCLIZATION

Doi:10.1016/S0040-4039(00)89287-4
(1985)
Structure-activity relationship studies at the benzodiazepine receptor (BZR): A comparison of the substituent effects of pyrazoloquinolinone analogs

Doi:10.1021/jm00063a017
(1993)
Assignment of absolute stereochemistry and total synthesis of (-)-spongidepsin

Doi:10.1021/ol049292p
(2004)
Spectroscopic Study of the Parent and Reduction Products of Some Substituted Bipyridine Complexes of Iron(II) and Osmium(II). 1. Substitution at the 5,5' Positions

Doi:10.1021/j100408a019
(1986)
Ergosteroids IV: Synthesis and biological activity of steroid glucuronosides, ethers, and alkylcarbonates

Doi:10.1016/S0039-128X(00)00234-8
(2001)

Article Doi