Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: Synthesis and biological activities

DOI: 10.1021/jm00018a027

Source and publish data:

Journal of Medicinal Chemistry p. 3660 - 3668 (1995)

Update date:2022-08-02

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Authors:

Gangjee Gangjee

Zaveri Zaveri

Kothare Kothare

Queener Queener

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Article abstract of DOI:10.1021/jm00018a027

Twenty 6-substituted 2,4-diaminotetrahydroquinazolines were designed, synthesized, and biologically evaluated as novel nonclassical inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. The 6

Full text of DOI:10.1021/jm00018a027

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