Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 11. Structure- activity relationships of several series of compounds derived from N- (chlorocarbonyl) isocyanate

DOI: 10.1021/jm00041a018

Source and publish data:

Journal of Medicinal Chemistry p. 2394 - 2400 (1994)

Update date:2022-08-04

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Authors:

Picard Picard

Bousley Bousley

Lee Lee

Hamelehle

Krause Krause

Minton Minton

Sliskovic

Stanfield

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Article abstract of DOI:10.1021/jm00041a018

Five series of compounds (4-9) derived from N-(chlorocarbonyl) isocyanate have been synthesized and evaluated for their ability to inhibit the enzyme acyl-CoA:cholesterol O-acyltransferase and lower plasma cholesterol levels in cholesterol-fed rats. Struc

Full text of DOI:10.1021/jm00041a018

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