4,5-Disubstituted primaquine analogues as potential antimalarial agents

DOI: 10.1021/jm00159a042

Source and publish data:

Journal of Medicinal Chemistry p. 1796 - 1798 (1986)

Update date:2022-08-04

Topics:

Authors:

Carroll Carroll

Berrang Berrang

Linn Linn

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00159a042

Three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against Plasmodium cynomolgi in rhesus monkeys. One of the compounds showed moderate activity; however, none of the three compounds were as active as

Full text of DOI:10.1021/jm00159a042

Products guided by the article

Product name:2-{4-[4-Chloromethyl-6-methoxy-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione

Cas No:102781-10-2

R&D Labs maybe for 102781-10-2

MiHecb Bio-Tech Co., Ltd.

Contact:+86-0592 5353131

Address:No.56 Guani Road Software Park 2,Siming District
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】

website:http://www.chemboss.com.cn

Contact:+86-531-58591595

Address:No2.Hualong Road, Jinan, China
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
SHIFANG SUHONG CHEMICAL CO.,LTD

Contact:+86-838-2224563

Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Acros Pharmatech Limited

website:http://www.acrospharmatech.com

Contact:+1-3234804688

Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong

Relevant to this article

Synthesis of highly functionalized pyrrole derivatives via a four-component reaction of two primary amines and diketene in the presence of nitrostyrene

Doi:10.1055/s-2008-1032168
(2008)
Enantioselective Synthesis and Absolute Configuration of Both Enantiomers of endo-Brevicomin

Doi:10.1021/jo00368a016
(1986)
Synthetic and Stereochemical Aspects of Intramolecular <4 + 2> Cycloadditions of N-Acyl Iminium Compounds with Alkene and Alkyne Dienophiles

Doi:10.1021/jo00366a047
(1986)
Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT

Doi:10.1016/j.bmc.2007.12.020
(2008)
Mild, efficient, and robust method for stereocomplementary iron-catalyzed cross-coupling using (E)- and (Z)-enol tosylates

Doi:10.1055/s-0030-1258131
(2010)
Double cyclometallation of bridging 3,6-bis(2-thienyl)-1,2,4,5-tetrazine in a dinuclear mesityl(dimethylsulfoxide)platinum(II) complex: Structure and properties

Doi:10.1016/j.jorganchem.2007.10.045
(2008)

Article Doi