ortho-Metalation/chlorination of benzoic acid derivatives: Preparation of [benzene-U-13C]-rac-Clopidogrel ([benzene-U-13C]-rac-SR25990C).

DOI: 10.1002/1099-1344(200008)43:9<891::AID-JLCR373>3.0.CO;2-0

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 891 - 898 (2000)

Update date:2022-07-29

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Authors:

Burgos, Alain

Herbert, John M.

Simpson, Iain

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Article abstract of DOI:10.1002/1099-1344(200008)43:9<891::AID-JLCR373>3.0.CO;2-0

Directed ortho-lithiation is used to form [benzene-U-¹³C]-2-chlorobenzaldehyde, the key building block for preparation of labelled racemic Clopidogrel ([benzene-U-¹³C]-rac-SR25990C). Some practical observations are reported concernin

Full text of DOI:10.1002/1099-1344(200008)43:9<891::AID-JLCR373>3.0.CO;2-0

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