Synthesis, chemical transformation and antimicrobial activity of a novel class of nitroolefins: 1,3-diaryl-2-nitroprop-1-enes

Article abstract of DOI:10.1080/00397919408011304

The synthesis of novel, biologically active 1,3-diaryl-2- nitroprop-1-enes (4) is reported. The synthesis involves condensation between aromatic aldehydes (1) and β-aryl nitroethanes (3). The chemical transformation of the nitro group in diaryl nitropropenes to a carbonyl function has resulted in a new route to the synthesis of an α-hydroxy analog (7c) of a naturally occurring 3,3',4,4'-tetramethoxy chalcone. The antimicrobial activity of the 1,3-diaryl-2-nitroprop-1-enes (4a- j) was tested against three gram positive bacteria, two gram negative bacteria and two fungi. These compounds exhibited broad spectrum antimicrobial activity.

Full text of DOI:10.1080/00397919408011304

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Synthetic Communications: An
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Organic Chemistry
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Synthesis, Chemical
Transformation and
Antimicrobial Activity of a
Novel Class of Nitroolefins: 1,3-
Diaryl-2-nitroprop-1-enes
Ram Prasad K. Kodukulla a , Girish K. Trivedi a , Jyoti
D. Vora a & Hari H. Mathur a
a Department of Chemistry, Indian Institute of
Technology, Powai, Bombay, 400076, India
Published online: 16 Feb 2007.
To cite this article: Ram Prasad K. Kodukulla , Girish K. Trivedi , Jyoti D. Vora & Hari
H. Mathur (1994) Synthesis, Chemical Transformation and Antimicrobial Activity of a
Novel Class of Nitroolefins: 1,3-Diaryl-2-nitroprop-1-enes, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
24:6, 819-832, DOI: 10.1080/00397919408011304
To link to this article: http://dx.doi.org/10.1080/00397919408011304
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