Roritoxins, New Macrocyclic Trichothecenes from Myrothecium roridum

Article abstract of DOI:10.1021/jo00365a010

Four new macrocyclic trichothecenes (roritoxins A-D) which contain a tetrahydropyranyl ring fused to a γ-lactone or lactol ring in the macrolide side chain were isolated from a culture of Myrothecium roridum ATCC 20605 grown on rice substrate.Roritoxin C is unique in that it is the first reported fungal-produced trichothecene which possesses a 9,10-epoxide group.In liquid media this fungal culture produces a new antibiotic, (+)-(1R,6R)-5-(S)-hydroxy-4-methyl-7-oxabicyclo<4.1.0>hept-3-en-2-one.