Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing a nitrooxy moiety at the 3-ester position

DOI: 10.1248/cpb.41.108

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 108 - 116 (1993)

Update date:2022-08-04

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Authors:

Ogawa Ogawa

Nakato Nakato

Tsuchida

Hatayama

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Article abstract of DOI:10.1248/cpb.41.108

The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.

Full text of DOI:10.1248/cpb.41.108

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