An efficient one-pot synthesis of polyphenolic amino acids and evaluation of their radical-scavenging activity

Article abstract of DOI:10.1016/j.bioorg.2019.102983

A simple and efficient procedure for the synthesis of N-acyl 4-hydroxy, 4-hydroxy-3-methoxy and 3,4-dihydroxy phenylglycine amides by a strategy based on the multicomponent Ugi reaction is proposed. Hydroxybenzaldehyde derivatives were reacted with 4-meth