Synthesis and cytotoxic activity of new 9-substituted camptothecins

DOI: 10.1016/j.bmcl.2008.04.016

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2781 - 2787 (2008)

Update date:2022-08-03

Topics:

Authors:

Dallavalle, Sabrina

Rocchetta, Daniela Granza

Musso, Loana

Merlini, Lucio

Morini, Gabriella

Penco, Sergio

Tinelli, Stella

Beretta, Giovanni Luca

Zunino, Franco

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Article abstract of DOI:10.1016/j.bmcl.2008.04.016

A series of novel 9-substituted camptothecins derived from 9-formylcamptothecin were synthesized. The aldehyde was obtained from 10-hydroxycamptothecin or, better, by total synthesis. The compounds showed antiproliferative activity higher than that of the

Full text of DOI:10.1016/j.bmcl.2008.04.016

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Product name:9-formyl-10-hydroxycamptothecin 10-tosylate

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