Stereospecific synthesis of functionalized C5-unsaturated hydantoin derivatives via a three-component reaction

Article abstract of DOI:10.1055/s-2008-1066993

An effective route to functionalized C5-unsaturated hydantoin derivatives is described. This involves the reaction of a urea derivative, derived from the addition of a primary amine to an aryl-sulfonyl isocyanate, and a dialkyl acetylenedicarboxylate in the presence of isoquinoline. Georg Thieme Verlag Stuttgart.