Synthesis and Antitumor Activity of Certain 3-β-D-Ribofuranosyl-1,2,4-triazolo-1,2,4-triazines Related to Formycin Prepared via Ring Closure of a 1,2,4-Triazine Precursor

DOI: 10.1021/jm00161a017

Source and publish data:

Journal of Medicinal Chemistry p. 2231 - 2235 (1986)

Update date:2022-07-29

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Authors:

Ramasamy, Kandasamy

Ugarkar, Bheemarao G.

McKernan, Patricia A.

Robins, Roland K.

Revankar, Ganapathi R.

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Article abstract of DOI:10.1021/jm00161a017

Several 3-β-D-ribofuranosyl-1,2,4-triazolo<3,4-f>-1,2,4-triazines related to formycin were prepared and tested for their antitumor activity in cell culture.Dehydrative coupling of 3-amino-6-hydrazino-1,2,4-triazin-5(4H)-one (5) with 3,4,6-tri-O-benzoyl-2,

Full text of DOI:10.1021/jm00161a017

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