Stereoselective syntheses of cytoxazone, a novel cytokine modulator, and its stereoisomers

DOI: 10.1016/S0040-4039(99)00712-1

Source and publish data:

Tetrahedron Letters p. 4203 - 4206 (1999)

Update date:2022-07-30

Topics: Regioselectivity Column chromatography Yield Chiral center Recrystallization Catalytic hydrogenation Stereoselective synthesis Enantiomers Optical rotation Stereoisomers HPLC (high-performance liquid chromatography) Protecting group Diastereomers Retrosynthetic analysis Chiral Resolution Coupling Reaction Oxazolidinone Cytoxazone NMR spectroscopy (Nuclear Magnetic Resonance)

Authors:

Sakamoto, Yasuharu

Shiraishi, Akiko

Seonhee, Jeong

Nakata, Tadashi

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Article abstract of DOI:10.1016/S0040-4039(99)00712-1

Cytoxazone, a novel cytokine modulator, and its stereoisomers were stereoselectively synthesized via stereocontrolled introduction of an azide group and direct construction of the 2-oxazolidinone ring from an azide carbonate by reductive cyclization.

Full text of DOI:10.1016/S0040-4039(99)00712-1

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