Journal of the American Chemical Society p. 9556 - 9565 (2008)
Update date:2022-08-05
Topics:
Champeil, Elise
Paz, Manuel M.
Ladwa, Sweta
Clement, Cristina C.
Zatorski, Andrzej
Tomasz, Maria
The cancer chemotherapeutic agent mitomycin C (MC) alkylates and cross-links DNA monofunctionally and bifunctionally in vivo and in vitro, forming six major MC-deoxyguanosine adducts of known structures. The synthesis of one of the monoadducts (8) by the
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