Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene

DOI: 10.1021/ja802118p

Source and publish data:

Journal of the American Chemical Society p. 9556 - 9565 (2008)

Update date:2022-08-05

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Authors:

Champeil, Elise

Paz, Manuel M.

Ladwa, Sweta

Clement, Cristina C.

Zatorski, Andrzej

Tomasz, Maria

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Article abstract of DOI:10.1021/ja802118p

The cancer chemotherapeutic agent mitomycin C (MC) alkylates and cross-links DNA monofunctionally and bifunctionally in vivo and in vitro, forming six major MC-deoxyguanosine adducts of known structures. The synthesis of one of the monoadducts (8) by the

Full text of DOI:10.1021/ja802118p

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