Synthesis p. 2398 - 2404 (2008)
Update date:2022-08-03
Topics:
Wang, Guangjun
Zhang, Hushan
Zhou, Jing
Ha, Chengyong
Pei, Duanqing
Ding, Ke
ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl] methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl] benzenesulfonamide were eff
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