Structural Studies on Bio-active Compounds. Part 3. Re-examination of the Hydrolysis of the Antimalarial Drug Pyrimethamine and Related Derivatives and Crystal Structure of a Hydrolysis Product

DOI: 10.1039/P19850002267

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2267 - 2276 (1985)

Update date:2022-08-04

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Authors:

Griffin, Roger J.

Schwalbe, Carl H.

Stevens, Malcolm F. G.

Wong, Kait P.

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Article abstract of DOI:10.1039/P19850002267

Hydrolysis of the diaminopyrimidine pyrimethamine and some of its 5-(3'-substituted)phenyl derivatives with 6M-hydrochloric acid or deamination with nitrous acid, affords mixtures of isomeric aminopyrimidinones.The ratio of products is influenced by the n

Full text of DOI:10.1039/P19850002267

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