Tetrahedron p. 5507 - 5516 (1985)
Update date:2022-08-04
Topics:
Barton, Derek H.R.
Togo, Hideo
Zard, Samir Z.
Radicals derived from thiohydroxamic esters 3 readily add to nitroolefins 5 (Z=NO2) to give good yields of α-nitrosulphides.These adducts, where the structure permits, are easily oxidised to carboxylic acids 8 by treatment with alkaline hydrogen peroxide.Reductive cleavage to the corresponding aldehydes or ketones 9 is efficiently carried out by the action of TiCl3.Addition of methyl magnesium iodide to methyl ketone derived from 3α-acetoxy 11-oxo cholanic acid gives steroid 10 possessing the 25-hydroxycholesterol side chain of the vitamin D3 metabolites.Radical additions to 1-phenylthio-2-nitropropene 11 have been briefly studied.
View MoreSuzhou HeChuang Chemical Co.,Ltd.
Contact:+86-512-88800520
Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Hangzhou innopharma technology Co,.Ltd.(expird)
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
Shandong Yubin Chemical CO.,LTD
website:http://www.yukaichem.com/en.html
Contact:+86-536-8865336
Address:binhai economic development zone，262737 shangdong，china
Zhejiang Chemline International Co., Ltd.
Contact:+86-571-88062298
Address:Hengdian Industry Area, Dongyang, Zhejiang, China
Hefei EnliPharma Tecnology Co.,Ltd
Contact:0086-551-66399836
Address:Qing Cheng ShuiXiang Building 805, Mengcheng North Road , ShuangFeng Economic Development Zone Anhui HeFei
Doi:10.1039/c8gc03166e
(2019)Doi:10.1248/cpb.35.4124
(1987)Doi:10.1016/j.tetasy.2003.11.008
(2004)Doi:10.1021/jm800239v
(2008)Doi:10.1021/ja00164a049
(1990)Doi:10.1016/j.tet.2008.05.033
(2008)
