Tetrahedron p. 5241 - 5260 (1985)
Update date:2022-07-31
Topics:
Baldwin, Jack E.
Cha, Jin K.
Kruse, Lawrence I.
A short and efficient total synthesis of racemic AT-125 and its racemic threo isomer proceeds via an intramolecular Michael cyclization of a protected α,β-dehydroglutamic acid γ-hydroxamate.Separation of diastereomers and deprotection to racemic AT-125 followed by enzymatic resolution of the N-chloroacetamide with hog-kidney acylase provides the natural αS,5S isomer.
View Morewebsite:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Contact:+86-10-59484199
Address:No.58-A1026 Liangguan Street
Shanghai Demand Chemical Co., ltd，China
Contact:86-021-55237578/55239122
Address:Room 3H, No.578, Yingkou Road, Yangpu District, Shanghai, China
Taizhou Shengxing Chempharm Co.,Ltd
Contact:+86-576-88516600
Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
website:http://www.u-chemo.com
Contact:+86-21-61558312
Address:Dong Fang Road,
Doi:10.1134/S1070428008060183
(2008)Doi:10.1039/DT9910002579
(1991)Doi:10.1021/om801117g
(2009)Doi:10.1016/j.poly.2012.07.088
(2013)Doi:10.1016/j.tetlet.2008.12.078
(2009)Doi:10.1002/jhet.5570240544
(1987)
