SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. RADICAL-INDUCED CYCLIZATION TO SUBSTITUTED BENZOFURANS, BENZOPYRANS, AND FUROPYRIDINES

Article abstract of DOI:10.1016/S0040-4039(00)95109-8

The ortho-iodoaryl allyl ethers 2, derived from 1 via the aromatic directed metalation protocol, undergo tributyl tin hydride-induced heteroring annelation to lead to unusually substituted benzofuran (3) and benzopyran, and furopyridine derivatives (Table).