Chemistry Letters p. 1005 - 1008 (1986)
Update date:2022-08-04
Topics:
Takaku, Hiroshi
Ito, Tsunehiko
Imai, Kazuaki
The 3,4-dimethoxybenzyl group was introduced to the 2'-hydroxyl group by the reaction of nucleosides with 3,4-dimethoxybenzyl trichloroacetimidate or 3,4-dimethoxybenzyl bromide-NaH.Further, this group can be used as a protecting group for the O6-amide group of the guanine residue.The protected nucleosides are useful starting materials for the synthesis of oligoribonucleotides.The 3,4-dimethoxybenzyl group was removed rapidly from the oligoribonucleotides by treatment with oxidizing agents without any damage to the glycosidic bonds.
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Doi:10.1016/S0040-4020(01)87547-5
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