MODELS OF FOLATE COENZYMES 16. CHEMICAL MODELLING OF THE THYMIDYLATE SYNTHASE REACTION. EVIDENCE FOR AN "EXOCYCLIC METHYLENE INTERMEDIATE" ANALOGUE, WHICH IS REDUCIBLE TO A THYMINE DERIVATIVE, IN THE REACTION OF 6-AMINOURACILS WITH A 5,10-METHYLENETETRAHY

DOI: 10.1016/S0040-4020(01)87547-5

Source and publish data:

Tetrahedron p. 3921 - 3930 (1986)

Update date:2022-08-04

Topics:

Authors:

Meij, Paul F. C. van der

Lohmann, Ruth D.

Waard, Eduard R. De

Chen, Tjoe B. R. A.

Pandit, Upendra K.

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Article abstract of DOI:10.1016/S0040-4020(01)87547-5

Reactions of 6-amino-, 6-alkylamino-, and 6-anilino-1,3-dimethyluracils (1a-1e) with 3,4-diphenyl-1-tosylimidazolidine (2), in the presence of acid, lead to the formation of products which are derived from an "exocyclic methylene intermediate" analogous t

Full text of DOI:10.1016/S0040-4020(01)87547-5

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