MODELS OF FOLATE COENZYMES 16. CHEMICAL MODELLING OF THE THYMIDYLATE SYNTHASE REACTION. EVIDENCE FOR AN "EXOCYCLIC METHYLENE INTERMEDIATE" ANALOGUE, WHICH IS REDUCIBLE TO A THYMINE DERIVATIVE, IN THE REACTION OF 6-AMINOURACILS WITH A 5,10-METHYLENETETRAHY

DOI: 10.1016/S0040-4020(01)87547-5

Source and publish data:

Tetrahedron p. 3921 - 3930 (1986)

Update date:2022-08-04

Topics:

Authors:

Meij, Paul F. C. van der

Lohmann, Ruth D.

Waard, Eduard R. De

Chen, Tjoe B. R. A.

Pandit, Upendra K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)87547-5

Reactions of 6-amino-, 6-alkylamino-, and 6-anilino-1,3-dimethyluracils (1a-1e) with 3,4-diphenyl-1-tosylimidazolidine (2), in the presence of acid, lead to the formation of products which are derived from an "exocyclic methylene intermediate" analogous t

Full text of DOI:10.1016/S0040-4020(01)87547-5

Products guided by the article

Product name:11-Benzyl-1,3,12-trimethyl-2,4-dioxo-1,3,4,5,6,11,11a,12-octahydro-2H-1,3,11,12-tetraaza-naphthacene-5a-carboxylic acid amide

Cas No:105159-31-7

R&D Labs maybe for 105159-31-7

Suzhou Time-chem Technologies Co., Ltd.

Contact:0512-63983931/68086856

Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK
Skyrun Industrial Co.,Ltd(expird)

website:http://www.chinaskyrun.com

Contact:0086-576-84610586

Address:Chemical Development Zone
Shanggao Ruiya Fine Chemicals Co., Ltd

Contact:+86-795-2592103

Address:Xingguang Nanlu,Shanggao County Industry Park
ZK Biochem Group Co., Ltd

Contact:+86-532-80762375

Address:No. 6, Hongkong Middle Road, Qingdao, China

Relevant to this article

N-Methylamino Pyrimidyl Amides (MAPA): Highly Reactive, Electronically-Activated Amides in Catalytic N-C(O) Cleavage

Doi:10.1021/acs.orglett.7b02288
(2017)
Multifunctional multivalency: A focused library of polymeric cholera toxin antagonists

Doi:10.1039/c0ob01089h
(2011)
Rh(I)-catalyzed ring-opening of hetaryne-furan diels-alder adducts: Rapid access to stereochemically defined heterocyclic scaffolds

Doi:10.1021/ol200057j
(2011)
5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior

Doi:10.1016/j.bmc.2010.11.055
(2011)
Synthesis of bromoallenyl pyrrolidines via 1,4-addition to 1,3-enynes

Doi:10.1007/s11426-010-4133-6
(2011)
OPLOPANES FROM THE LEAVES OF SENECIO MEXICANUS

Doi:10.1016/0031-9422(90)80060-T
(1990)

Article Doi