AN ACETAL GROUP SUITABLE FOR THE PROTECTION OF 2'-HYDROXY FUNCTIONS IN RAPID OLIGORIBONUCLEOTIDE SYNTHESIS

Article abstract of DOI:10.1016/S0040-4039(00)84511-6

The 1-<(2-chloro-4-methyl)phenyl>-4-methoxypiperidin-4-yl has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protecting group under mild hydrolytic conditions ; however, under the relatively more drastic conditions required for the complete removal of a 9-phenylxanthen-9-yl (Px) group, the Ctmp protecting group remains virtually intact.