A General Strategy for the Synthesis of Monohydroxyeicosatetraenoic Acids: Total Synthesis of 5(S)-Hydroxy-6(E),8,11,14(Z)-eicosatetraenoic Acid (5-HETE) and 12(S)-Hydroxy-5,8,14(Z),10(E)-eicosatetraenoic Acid (12-HETE)

DOI: 10.1055/s-1986-31612

Source and publish data:

Synthesis p. 344 - 347 (1986)

Update date:2022-08-02

Topics:

Authors:

Nicolaou, K. C.

Ladduwahetty, T.

Taffer, I. M.

Zipkin, R. E.

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Article abstract of DOI:10.1055/s-1986-31612

Stereocontrolled total syntheses of 5(S)-hydroxy-6(E),8,11,14(Z)-eicosatetraenoic acid (5-HETE) and 12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid (12-HETE) via palladium(0)-copper(I) coupling technology are described.

Full text of DOI:10.1055/s-1986-31612

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