Bioorganic and Medicinal Chemistry Letters p. 4470 - 4473 (2008)
Update date:2022-09-26
Topics:
Hilfiker, Mark A.
Zhang, Daohua
Dowdell, Sarah E.
Goodman, Krista B.
McAtee, John J.
Dodson, Jason W.
Viet, Andrew Q.
Wang, Gren Z.
Sehon, Clark A.
Behm, David J.
Wu, Zining
Carballo, Luz H.
Douglas, Stephen A.
Neeb, Michael J.
Aminomethylpiperazines, reported previously as being κ-opioid receptor agonists, were identified as lead compounds in the development of selective urotensin receptor antagonists. Optimized substitution of the piperazine moiety has provided high affinity u
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(2008)
