A Stereocontrolled Synthesis of an Important Intermediate for the Preparation of 1β-Methylcarbapenem Antibiotics

DOI: 10.1021/jo00388a039

Source and publish data:

Journal of Organic Chemistry p. 2563 - 2567 (1987)

Update date:2022-08-05

Topics:

Authors:

Fuentes, L. M.

Shinkai, I.

King, A.

Purick, R.

Reamer, R. A.

et al. et al.

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Article abstract of DOI:10.1021/jo00388a039

A stereocontrolled chiral synthesis of the 1β-methylcarbapenem antibiotic precursor 3b has been accomplished.The factors influencing the stereochemical outcome of the catalytic hydrogenation of the 1-azabicyclo<4.2.0>octanes 4 and 12 are presented.

Full text of DOI:10.1021/jo00388a039

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