Electrochemical Decarboxylation of Hydroxyproline: A Simple Three-Step Conversion of (2S,4R)-4-Hydroxyproline to (R)-γ-Amino-β-hydroxybutanoic Acid (GABOB)

Article abstract of DOI:10.1055/s-1986-31665

A high yield conversion on preparative scale of (2S.4R)-N-acetyl-4-hydroxyproline (1) to (R)-GABOB (4) is reported.The key step of the synthesis is the electrochemical oxidative decarboxylation of 1.