Electrochemical Decarboxylation of Hydroxyproline: A Simple Three-Step Conversion of (2S,4R)-4-Hydroxyproline to (R)-γ-Amino-β-hydroxybutanoic Acid (GABOB)

DOI: 10.1055/s-1986-31665

Source and publish data:

Synthesis p. 424 - 426 (1986)

Update date:2022-08-04

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Authors:

Renaud, Philippe

Seebach, Dieter

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Article abstract of DOI:10.1055/s-1986-31665

A high yield conversion on preparative scale of (2S.4R)-N-acetyl-4-hydroxyproline (1) to (R)-GABOB (4) is reported.The key step of the synthesis is the electrochemical oxidative decarboxylation of 1.

Full text of DOI:10.1055/s-1986-31665

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