Tetrahedron p. 3761 - 3770 (1988)
Update date:2022-07-29
Topics:
Anwar, S.
Davis, A.P.
A study was made of the synthesis and intramolecular hydrosilylation of silyloxyketones (2) (Sheme 2).It was found that with a variety of Lewis acid catalysts, anti-selective hydrosilylation took place to give (3) and, after desilylation, (5).With SnCl4, the most effective and practical catalyst, ratios (3):(4) ranged between 40:1 and 120:1 for a number of substrates.An explanation for the stereoselectivity is proposed based on (Cl) as a transition state model.The result is an anti-selective reduction of β-hydroxyketones, summarised in Scheme 4.
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