The Enantioselective Microbial Reduction of Methyl (+/-)-5-Chloro-2-oxobicycloheptane-7-anti-carboxylate

Article abstract of DOI:10.1055/s-1986-31728

Methyl (+)- and (-)-5-chloro-2-oxobicyclo<2.2.1>heptane-7-anti-carboxylates, useful intermediates in prostaglandin synthesis, are prepared on a preparative scale from the racemic compound by two routes using enantioselective microbial reduction as a key-step.