5-Quinone Derivatives of 2'-Deoxyuridine 5''-Phosphate: Inhibition and Inactivation of Thymidylate Synthase, Antitumor Cell, and Antiviral Studies

DOI: 10.1021/jm00385a026

Source and publish data:

Journal of Medicinal Chemistry p. 409 - 419 (1987)

Update date:2022-09-26

Topics:

Authors:

Al-Razzak, Laman A.

Schwepler, Douglas

Decedue, Charles J.

Balzarinr, Jan

Clercq, Erick De

Mertes, Mathias P.

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Article abstract of DOI:10.1021/jm00385a026

Both photochemical aromatic substitution and palladium(0)-catalyzed biaryl coupling reactions have been employed in the synthesis of 5-substituted 2'-deoxyuridines.The former procedure was useful in the preparation of the 3,4-dimethyl-2,5-dimethoxyphenyl

Full text of DOI:10.1021/jm00385a026

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